Hello.
From the logs you sent, I could see that "Remote to Local" failure is caused by the new web portal cannot negotiate the Extended Clipboard virtual channel, resulting in the rejection of the EnterpriseDataProtectionId (Format 49283) metadata.
You could try to verify that the rdpclipcdv.exe executable, located in the SxS Network Stack path under C:\Program Files\Microsoft RDInfra, is not being blocked by AppLocker or your antivirus, as this process is now responsible for handling these modern clipboard formats. Additionally, check your Host Pool RDP properties to ensure that no specific data types are being filtered via clipboardblockeddatatypes, as the new shell may be defaulting to a "block" on some formats when negotiation fails.
I would recommend continuing to use the old web client URL for affected users while Microsoft stabilizes the feature for the new URL.
If you find my answer useful, you can mark it as the "Accepted Answer" so the others can find the solution easily. Your help in supporting the community is much appreciated! Thanks