A family of Microsoft spreadsheet software with tools for analyzing, charting, and communicating data.
The first consideration is What has changed on the Mac?
The most common cause is a matter of updates. Confirm that your version of macOS is fully updated as well as your Office software. Additionally, check the device manufacturer's support site for an updated driver for that specific keyboard.
For the time being you can disregard the message from the Q&A Assist bot. That only needs to be done if deviating from the Operating System settings is required. Excel takes uses the macOS settings for that as well as related features. If all is current but the issue persists, quit all Programs then go to > System Settings> General> Language & Region to confirm the correct choices for Region & for Number Format as well as any others which need to be adjusted. Restart the Mac after making any changes.